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MB upregulates the expression of Nrf2 and its downstream antioxidant genes The nuclear factor erythroid 2-related factor 2 (Nrf2) is known as an essential regulator of antioxidant defense system by inducing the expression of an array of antioxidant response element (ARE)-containing genes, thereby decreasing overall cellular ROS 22

Individual injection costs may typically range from $35 to $75 per shot [7] , while some providers may offer packages that may reduce the per-injection cost